Frédéric Aubriet, Vincent Carré
Chapitre d’ouvrage dans “Fundamentals and Applications of Fourier Transform Mass Spectrometry » Elsevier 281-322 (2019). DOI

Travail réalisé sur le site de l’Université de Lorraine.

Abstract

Among the numerous ion sources coupled to Fourier transform ion cyclotron resonance mass spectrometers, the laser-based ion sources have a key role. Pulsed lasers have the unique ability to generate neutrals and/or ions from a condensed or gaseous sample in a non-invasive way and to be focused on a very thin area. Depending on both the laser beam and the sample features, various processes could happen during laser–matter interaction that directly impact the detected ions. In this chapter, the factors driving this interaction will be firstly described especially to understand that leading to : the laser desorption (LD), desorption/ionization with (MALDI) or without (LDI) matrix assistance and the laser ablation (LA). The resulting technical advances of laser ion sources, including those, which operate under atmospheric pressure are explained in detail in this chapter for achieving robust FT-ICR-MS measurements. The advent of high performance imaging mass spectrometry using laser ion sources also push up some new developments which will be summarized. A great number of applications demonstrate the versatility of the combination of laser and FT-ICR-MS and some of them will be illustrated in a last section.