TGE FT-ICR


Partenaires

CNRS
Logo Ecole Polytechnique Logo ESPCI
Logo UPS Logo UDL
Logo UPMC Logo Universite de Lille 1
Logo Rouen Logo INSA Rouen Normandie



Accueil du site > Production scientifique > Interaction of Cisplatin with 5′-dGMP : A Combined IRMPD and Theoretical Study

Interaction of Cisplatin with 5′-dGMP : A Combined IRMPD and Theoretical Study

Date de publication: 23 mars 2015

B. Chiavarino, M.E. Crestoni, S. Fornarini, D. Scuderi, J.-Y. Salpin
Inorg. Chem. 54 3513−3522 (2015). DOI

Travail réalisé sur le site de l’Université Paris Sud.

Abstract

The characterization of cis-[Pt(NH3)2(5′-dGMP−H)]+ ion points to macrochelate species resulting from the simultaneous interaction of the metal with both the N7 atom of the guanine residue and an O atom of the phosphate group. In contrast, IRMPD spectra of cis-[PtCl(NH3)2(5′-dGMP)]+ are consistent with a monodentate complex involving exclusively the N7 position of guanine. Also this species exhibits a compact shape due to the formation of two hydrogen bonds involving the same ammonia ligand